Watch the video overview, then download the AACR 2026 poster for the full workflow and data. ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏  ͏ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­  

Inventia-Life-Science_Logo_HighRes_Pink (2) (1)Discovery Services Email Banner

 

Custom 3D Model Development: Discovery Services

 

Not every research question fits a predefined model. Inventia Discovery Services helps teams develop, run, and transfer RASTRUM-based 3D disease models aligned to their biology, therapeutic question, assay readouts, and context of use.

 

From tumor-stroma and tumor-immune models to fibroblast activation, stromal biology, neurodegenerative disease, and custom disease model development, Discovery Services can help teams move from research question to interpretable 3D data.

 

Explore Discovery Services

 

DDN Symposium_August 26-27 2026_Advances in immuno-oncology

 

Upcoming Webinar: Advances in Immuno-oncology

 

Join Inventia Life Science at Advances in Immuno-Oncology, a live virtual symposium hosted by Drug Discovery News on August 26 to 27, 2026.

 

This two-day event will bring together researchers discussing the latest advances in cancer immunology, from tumor-immune interactions and immunotherapy strategies to mechanisms of resistance and clinical translation. As part of the program, Inventia's Matthieu Spriet PhD will present a 20-minute session on how biologically relevant 3D models can support immune-tumor research, including a preview of a new RASTRUM Validated Solution launching soon!

 

Register for the webinar

 

Workflow Paths

 

Workflow Paths: Find the Solution that Fits Your Research Needs

 

Your 3D model strategy depends on where you are starting and what question you need to answer.

  • Validated Solutions provide predefined model blueprints for specific applications and contexts of use.
  • Discovery Mode gives teams flexibility to develop and refine RASTRUM-based 3D models around their own biology, readouts, and workflow needs.
  • Discovery Services offers scientific support for custom model development when your question requires a more tailored approach.

Together, these workflow paths help research teams match the right level of structure, flexibility, and support to their goals.

 

Find your path

 

Inventia Insights

 

Inventia Insights: Getting More from 3D Models

 

This month’s blog updates focus on what happens before and beyond the model build: how to prepare for a stronger first RASTRUM print and how advanced in vitro workflows can help bridge the gap between simplified culture systems and complex in vivo biology.

 

New! Before Your First RASTRUM Print: 10 Tips for a Stronger Start
Planning a successful 3D print starts before cells enter the printer. This practical guide helps new RASTRUM users think through matrix selection, cell health, controls, assay design, and how to use prior 2D or 3D experience to build a stronger starting workflow.
Get the tips

New!
In Vivo to In Vitro: My Journey Supporting Science
What happens when someone who spent 12 years supporting in vivo and preclinical research turns their focus to advanced 3D cell culture? In this perspective piece, Sal DiLisio reflects on the translational gap between traditional in vitro models and in vivo biology, and why more biologically relevant 3D workflows can help researchers ask better questions earlier in discovery.
Read Sal's story →

Related reading: The Rise of 3D Models: From Buzz to Benchside Reality
A conversation with Morgan Hamon PhD on how 3D models are becoming more practical for biomedical research, from better biological relevance to the reproducibility and scale needed for everyday workflows.
Read the article

Scientific Spotlight: CAFs and T-cell killing in 3D PDAC

Pancreatic tumors contain dense, fibrotic stromal regions that can create protective niches for cancer cells and limit effective antitumor immune responses. Models that omit stromal components may therefore miss a key contributor to immune evasion and reduced immune-mediated cancer-cell killing.

 

In this video overview, Matthieu Spriet, PhD, walks through research led by Aji Istadi and colleagues at the Garvan Institute of Medical Research. Using RASTRUM™ Allegro, the team built multicellular 3D pancreatic cancer models incorporating KPC cancer cells, cancer-associated fibroblasts, cytotoxic T cells, and defined matrix components.

 

Watch the AACR 2026 video presentation on CAFs and T-cell killing in 3D pancreatic cancer models

Watch the video overview to see how the model was used to study tumor growth, stromal activation, immune-cell infiltration, and T-cell-mediated cancer-cell killing.

 

Key finding:

In this model, adding cancer-associated fibroblasts reduced cytotoxic T-cell-mediated cancer-cell killing, consistent with a protective stromal effect.

 

Download the full poster to explore:

  • Quantified cytotoxic T-cell infiltration and cancer-cell contact in RASTRUM and basement membrane extract co-cultures
  • CAF growth and alpha-SMA positivity as a marker of fibroblast activation
  • Single-cell RNA-seq comparison showing gene-expression overlap with KPC tumors and disease-relevant cell subtypes
  • Functional cancer-cell killing by cytotoxic T cells with and without CAFs