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Molecular Devices

ImageXpress Pico Automated Cell Imaging System

pico benchtop
The ImageXpress® Pico Automated Cell Imaging System combines high-resolution imaging and powerful analysis, with a streamlined workflow. It includes CellReporterXpress® software for acquisition and analysis, and features a comprehensive portfolio of preconfigured protocols. The automated setup of analysis parameters shortens the learning curve, so you can start running experiments quickly. If you’re in the market for fluorescence imaging or digital microscopy, the ease and affordability of an automated imager is now within reach.


Automated fluorescence imaging that’s easier than digital microscopy

  • Get started quickly

    Get started quickly

    With the approachable, icon-driven CellReporterXpress software, everyone can use the ImageXpress Pico system with minimal training to capture and analyze your first image.

  • Do more than cell counting

    Do more than cell counting

    Expand your assays beyond cell counting with preconfigured templates for many commonly used cell imaging and analysis protocols such as apoptosis and detection of mitochondria.

  • Cost Effective

    Image economically

    Alleviate the hassle of going to the core lab to run your samples. The system’s lab-friendly price affords the convenience of automated imaging and analysis on your lab bench.


  • Multiple imaging modes

    The ImageXpress Pico system provides user- and software-selectable objectives ranging from 4X to 63X, fluorescence imaging, live cell imaging, and brightfield imaging modes.

  • Predefined cell imaging protocols

    The system offers preconfigured cell imaging protocols ranging from simple cell count to sophisticated neurite tracing analysis, removing the guesswork from optimizing parameters.

  • Plate-to-individual cell view

    Data can be visualized at multiple levels from plate overviews to individual cells. Images are clickable to locate cells that match specific criteria.

  • Integrated data visualization tools

    Liberate your lab from tedious digital microscopy, the software transforms images into data on the fly. Scatter plots, videos, and more can be generated automatically with just a few clicks.

  • Advanced slide scanning workflow

    Whole slide scanning, for the determination of regions of interest, is quick and easy. Acquires higher resolution scans of only the select regions, saving time and data storage.

  • Temperature control

    Temperature control up to 40◦C is standard on every ImageXpress Pico system, making live cell imaging a possibility.


Műszaki specifikációk

General specifications

5 megaPixel CMOS Camera

Field of View with 10x: 1.93 mm2

4x-63X Air objectives

5 position filter cube changer

LED + image autofocus

Transmitted Light


Z-stack option

Digital confocal option

Up to 384-well plates & Microscope slides

Temperature control


CellReporterXpress Analysis Software



Applications of ImageXpress Pico Automated Cell Imaging System

The CellReporterXpress Automated Image Acquisition and Analysis Software works with the ImageXpress® Pico systems. It has a clean, easy-to-learn interface for performing quantitative analysis on images acquired from automated microscopy. The software enables distributed analysis of images for increased throughput and is ideal for scaling microscopy imaging with slides or microplates. An icon-driven, linear workflow with a range of predefined protocols provides a streamlined user experience.

  • Analyze during acquisition

    Analyze during acquisition

    Reduce the time to run experiments with our integrated on-the-fly image analysis capability, allowing you to view numeric data during acquisition.

  • Protocols

    Simplify image analysis

    Predefined analysis protocols for label-free and fluorescence imaging provides you with the ability to quickly run common biological assays while still allowing you to create and save your own protocols.

  • Share and access data from anywhere

    Share and access data from anywhere

    The software makes sharing, presenting, and collaborating with peers easier, allowing multiple you to utilize the software simultaneously through browser-based remote access.


  • Region selection for acquisition

    Multiple unique positions within a well or slide can be selected to acquire and analyze only key areas of interest.

  • Label-free analysis

    Automatically identifies objects in brightfield including small round cells, large cells, and beads.

  • Click-to-find feature

    This feature auto calculates object parameters based on user-selected cells of interest, simplifying analysis setup for cell counting and for cellular responses.

  • Side-by-side cell magnification

    Zoom or pan high-resolution images from whole well view down to cell level view. Simultaneously compare images from two wells.

  • Touch screen capability

    Exceptional usability and precise control is built-in whether using a personal computer or a tablet.

  • Browser-based software

    The ImageXpress Pico system can be controlled through a browser with data from any computer on the user’s network via Chrome™ or Safari®.

  • Apoptosis Analysis

    Apoptosis is a process of programmed cell death important to a number of biological processes including embryonic development and normal tissue maintenance. Disruption in the regulation of apoptosis has been implicated in various diseases including cancer. Biochemical events lead to characteristic changes in cell morphology such as cell shrinkage, nuclear fragmentation, chromatin condensation, and mRNA decay, and ultimately cell death. Apoptosis can be initiated via the intrinsic or extrinsic pathways, and both pathways induce cell death by activating caspase enzymes


    Apoptosis Analysis
  • Cell Counting

    Cell counting is fundamental and critical to numerous biological experiments. Assays such as drug compound toxicity, cell proliferation, and inhibition of cell division have a need to assess the number or density of cells in a well. Automated imaging can greatly speed up the cell counting process while reducing manual labor and human errors. Cells can be counted using a variety of methods, such as label-free cell counting under transmitted light or detection of nuclear dye with fluorescent imaging.

    Cell Proliferation



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