
CELL RESEARCH: Whole organism modeling is sometimes necessary in order to complement and substantiate cell culture data. Some cellular phenomena can only be modeled by exposure of whole organisms during different stages of development to various physiologic gases. Not surprising, these are the same gases important for cells in the dish. In contrast to cells in vitro, cellsin vivo still have local communication ties to neighboring cells. They also still have humoral and neural communication lines to distant cells and organs intact. These communications are some of the most difficult simulations to create in vitro, even for Cytocentric cell incubation and processing.
DISEASE RESEARCH: Animal models of the disease are often necessary to discover the underlying molecular, genetic, and cellular mechanisms causing the disease, and to develop new therapeutic approaches.
DRUG DEVELOPMENT: Animal models are absolutely necessary for pre-clinical testing of new pharmaceuticals in order to assure safety and efficacy before testing in humans.
THERAPEUTIC MODELING: Animal models are necessary for refining traditional respiratory therapies and developing new respiratory therapies.
Equipment consists of various chambers designed to hold animal cages and various compatible controllers that generate appropriate physiologic or pathologic exposures inside the chambers to create the models.
Chronic exposures to hypoxia, hyperoxia, and hypercapnia can be simulated with ProOx/ProCO2controllers |
Simultaneously simulate multiple dynamic O2/CO2/CO/NO exposures with our OxyCycler series of controllers |
Sleep apnea modeling: |
Ischemia-reperfusion modeling: |
Retinopathy of prematurity modeling: |
Pulmonary hypertension modeling: |
Hypercapnia model for lung injury: |
Ocular angiogenesis modeling: |
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