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Axion BioSystems

Maestro ZHT

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Axion BioSystems’ Maestro ZHT platform measures cell proliferation, death, morphology, attachment, and signaling label-free and in real time. Screen drug and biological candidates in a 384- and 96-well plate formats. Track immune cell-mediated killing, viral infectivity, cancer cell invasiveness, endothelial barrier function, wound healing, and more.

These high-throughput assays are real-time, continuous, and label-free, revealing the full cellular response profile and kinetics using electrical impedance. Get more complete data without the time- and cost-intensive process of repeating multiple endpoint assays.

ÁRAJÁNLATOT, INFORMÁCIÓT KÉREK!

 

Taking care of the assay so you can focus on the science.

  • High-throughput, continuous monitoring of your cells - Up to 384 simultaneous live recordings from your cells. The Maestro ZHT system performs noninvasive electrical measurements from the cultured cell population, circumventing the use of dyes/reporters that can perturb your cell model and confound results. Track activity over hours, days, and weeks from the same population of cells label-free and in real time.

  • Precisely control the cells' environment - There is no need for an additional cell culture incubator, saving valuable lab space and money. Maestro Z’s smart environmental chamber finely controls temperature and CO₂ while rejecting electrical noise and mechanical vibrations.

  • Start your assay with the push of a button - “One button setup,” means temperature and CO₂ levels automatically adjust on plate docking. Plate usage is logged via an integrated plate barcode scanner for convenient experiment tracking.

  • Review your results faster - The Impedance module with AxIS Z software provides a simplified approach to the setup, execution, and analysis of experiments.

  • Achieve 21 CFR Part 11 compliance in GLP/GMP labs - Designed with clinical translation and a regulatory environment in mind, the optional GxP Impedance Module makes the assay easy to validate and fully auditable while maintaining many of the streamlined and user-friendly features of AxIS Z.

 
  • Validate your assay for high throughput screening - A 384-well cytotoxicity assay using the Maestro ZHT was validated for high throughput screening, achieving high Z' ( Z'=0.81, n=2 ) with no edge effects.

  • Monitor your experiments from outside the lab - The Maestro Z App allows you to check in on your cells and experiment to ensure everything is running smoothly while you are away from the lab.

  • Increase throughput with multiple Maestros - Continuously monitor multiple plates automatically and simultaneously with multiple Maestro support. Save space in your lab by controlling multiple Maestro systems using a single computer.

Multiple Maestro Z support available

Overview

Cell-based assays are critical to evaluate human biology in vitro. Many cell-based assays, however, are limited to a single snapshot in time. These endpoint assays can miss important events in cell proliferation, death, and signaling. Axion BioSystems’ Maestro ZHT platform offers continuous, label-free, impedance-based monitoring of your cells. Reveal the detailed kinetics of cell signaling interactions, cytotoxicity, and a host of drug responses for a better biological understanding without the time- and cost-intensive process of repeating multiple endpoint assays.

Maestro Z product family
Impedance software modules for Maestro Z

Software

The Maestro ZHT system is available with two software modules: Impedance and GxP Impedance. Select the software modules to match your assay needs:

Impedance – Track cell proliferation, morphology, and viability label-free and in real-time. Ideal for immuno-oncology, cytotoxicity, virology, cell migration, cell proliferation, GPCR assays, and many more.

GxP Impedance – Achieve FDA 21 CFR Part 11 compliance in GMP/GLP labs with this version of the Impedance Software Module.

Cells growing to confluence over microelectrode array

Consumables

The Maestro ZHT system is compatible with the both 384- and 96-well impedance assay plate.

CytoView-Z – The Maestro impedance plate with a transparent well bottom for cell visualization and assay multiplexing. Available in a 384-well and 96-well plate formats.

 

Műszaki specifikációk

Maestro Z product family

Applikációk

Related Applications

Antiviral Drug Studies
Evaluate the antiviral effects of test compounds by tracking real-time changes in cytopathic effects
Barrier Function
Monitor cell barrier integrity using a TEER (transepithelial or transendothelial resistance) assay
Cancer Spheroid
Model complex solid tumor biology to investigate the in vitro effects of immunotherapies and other anticancer agents
Cell Migration and Invasion
Track cell migration and proliferation for advanced metastatic cancer or wound-healing studies
Cell Proliferation
Reveal the kinetics of cellular proliferation and for improved insights of cell models
Cell Signaling
Measure the dynamics of GPCR cell signaling over minutes to hours label free
Cytotoxicity and Cell Viability
Evaluate cell viability and characterize the cytotoxic properties of compounds in acute and chronic exposure experiments
Immuno-oncology
Evaluate killing kinetics of immune cells (e.g. CAR T or NK) at physiologically relevant effector cell to target cell ratios
Liquid Tumors
Study hematological cancer models with non-adherent cells to develop the next generation in blood cancer therapies
Viral Titer
Quantify the infectious virus in a sample by monitoring the cytopathic effects in real time
Tartozékok, kiszerelések

 

Impedance software modules for Maestro Z

Software

The Maestro ZHT system is available with two software modules: Impedance and GxP Impedance. Select the software modules to match your assay needs:

Impedance – Track cell proliferation, morphology, and viability label-free and in real-time. Ideal for immuno-oncology, cytotoxicity, virology, cell migration, cell proliferation, GPCR assays, and many more.

GxP Impedance – Achieve FDA 21 CFR Part 11 compliance in GMP/GLP labs with this version of the Impedance Software Module.

Cells growing to confluence over microelectrode array

Consumables

The Maestro ZHT system is compatible with the both 384- and 96-well impedance assay plate.

CytoView-Z – The Maestro impedance plate with a transparent well bottom for cell visualization and assay multiplexing. Available in a 384-well and 96-well plate formats.

 

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