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Sciex Separations

CESI 8000 Plus High Performance Separation-ESI Module

Rebranded CESI8000_with scientist
HD_CESI 8000_view 01_v5_12.17
For research use only. Not for use in diagnostic procedures.

Extending the reach of your mass spectrometer

Mass spectrometry (MS) has become an indispensible technology for the analysis of compounds of biological interest. Improvements in assay sensitivity and reduction in ion suppression offered by the CESI 8000 reveal new information that is critical to your research, whether you're characterizing a therapeutic protein, identifying the proteins that make up a specific proteome, analyzing post-transitional modifications, or studying a metabolomic fingerprint. This new front-end separation and ionization technology called CESI integrates the high efficiency of capillary electrophoresis (CE) with electrospray ionization (ESI) and produces an ultra-low flow < 25 µL/min, which is the reason for the increased ionization efficiency.

For every researcher there is an ideal analytical technology—one that helps you achieve your goals.


Advantages of CESI-MS Ultra-low flow separation-ESI

    • Minimize ion suppression
    • Maximize ionization efficiency
    • Increase sensitivity
    • New analytes discovered, identified, and quantified
    • Non-tapered, open-tube capillary, with no dead volumes - maximizing peak efficiency and sensitivity
    • High resolution separation without a stationary phase: no small peptides lost in the flow-through and no large peptides excessively retained
    • No time lost on minimizing void volumes and dealing with clogging
    • No sample carry-over
    • Orthogonal and/or superior coverage to other technologies

CESI 8000 High Performance Separation

Easy-to-use OptiMS cartridge

    • Plug-and-spray design
    • Interfacing with MS is fast and easy

Higher throughput

    • Open-tube capillary design doesn't require lengthy column equilibration
    • Decreased injection-to-injection time

CESI mobile design

    • Equipped with a height adjustable mobile bench
    • Switching between LC/MS and CESI-MS has been made swift and simple
High performance separation and 
ESI module upstream from MS
CESI technology

Improved ionization efficiencies result in reduced ion suppression and increased overall sensitivity.

Designed for mass spectrometry applications that analyze charged and polar molecules, the CESI 8000 is the next evolution in technology. With CESI-MS the advantages of CE are delivered without dilution or disturbance to the mass spectrometer. Stable ultra-low flow ESI serves to reduce ion suppression and increases sensitivity.

Unleash the power of CE separation for the best in mass spectrometry detection.

The OptiMS cartridge assembly consists of a separation capillary terminating in the porous sprayer, a conductive liquid capillary, circulating liquid cooling, and sprayer housing. Conductive fluid is delivered automatically from a system vial that completes the CE circuit. This capillary is housed in a protective cartridge that allows easy transfer and routine use in a rugged and robust manner. With the CESI 8000 system, the cartridge simply clicks into place creating an easy-to-use plug-and-spray set up for your mass spectrometry.

The CESI 8000 was developed in collaboration with mass spectrometry researchers covering a number of applications. They sought to expand their range of detection and increase sensitivity. In order to achieve this goal, a low flow pre-MS separation technology was integrated with novel ESI coupling technology.

Swift and simple "plug-and-spray" design increases operational efficiency

    • Automated sample handling from microvials
    • Simple interfacing with automatic triggering of MS data collection
    • Easy switching between liquid chromatography (LC) and CESI-MS

CESI 8000


Located within a protective housing, the CESI 8000's sprayer combines an intrinsically low-flow CE separation with electrospray ionization (ESI) within a single, simple device that has no liquid junction or dead volume.

    • Capillary's distal end is porous to allow ion flow
    • Electrical contact for the CE is achieved through an ESI needle filled with conductive fluid
    • ESI's electrical contact is achieved through the protruding capillary tip
    • Low flow at the tip terminus instantly generates a fine spray when ESI voltage is applied
    • All electrochemistry associated with electrolysis of water is hereby decoupled from the spray
    • Capillary inlet and exit are of the same dimension, reducing the clogging often associated with nanoscale techniques
    • ESI is generated at lower voltages, which reduces the risks of oxidation artifacts

CESI 8000 Software

1Kelly RT, Page JS, Zhao R, Qian W, Mottaz HM, Tang K, Smith RD, Anal. Chem. 2008, 80, 143-149
2Schmidt A, Karas M, Dulks T, J. Am. Soc. Mass Spectrom. 2003, 14, 492-500
3Reprinted with permission from "High Capacity Capillary Electrophoresis-Electrospray Ionization Mass Spectrometry: Coupling a Porous Sheathless Interface with Transient-Isotachophoresis" by Jean-Marc Busnel et al. (2010) Analytical Chemistry 82 (22), 9476-9483.


Műszaki specifikációk

A98089: CESI 8000 High Performance Separation- ESI Module
Includes CE separation module, OptiMS Sprayer cartridges, system controller pre-loaded with CESI 8000 software, portable height-adjustable lab bench designed for rapid change between LC and CESI front end.

Height: 29.2 in (74.2 cm)
Door Open: 38.8 in (98.6 cm)
Width: 25 in (63.5 cm)
Depth: 28.4 in (72.1 cm)

Height Adjustable Portable Lab Bench with Memory Settings:
36 in x 30 in (91.4 cm x 76.2 cm)
Height adjustable from 27 in to 44 in (69 - 112 cm)

Weight (uncrated):
188 lbs (85.3 kg)

Electrical Requirements:
Voltage: 100 - 240 V; 50/60 Hz

Voltage Range:
1 to 30 kV programmable
at 0.1 kV increments

Current Range:
3 to 300 μA programmable
at 0.1 μA increments

Operating Environment Range:
15 - 30°C
20 - 60% relative humidity (non-condensing)

Sample Trays:
2 x 48 CESI vials / 0.3 mL microvials

Buffer Tray:
2 x 36 CESI vials

Sample Temperature Adjustment Range:
4 - 60°C

Capillary Temperature Adjustment Range:
15 - 30°C

Pressure Delivery Range:
-5 to +100 psi

Required Sample Volume:
50 μL

Tartozékok, kiszerelések

A98089: CESI 8000 High Performance Separation- ESI Module
Includes CE separation module, OptiMS Sprayer cartridges, system controller pre-loaded with CESI 8000 software, portable height-adjustable lab bench designed for rapid change between LC and CESI front end.

Videók, ismertetők

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