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GeSiM

BioScaffolder prémium 3D bionyomtatók

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Customizable 3D-Bioprinters

Additive manufacturing (AM) for tissue engineering (TE) and regenerative medicine combines biocompatible/biodegradable polymers with living cells. GeSiM 3D bioprinters can create bioscaffolds for cell growth or deposit layers of bioinks on implants or microfluidic objects. However, artificial bones, skin, organoids still not reach their originals made by nature. Research on this subject requires flexible lab equipment, compatible even with new tools and accessories still to be developed.

Our bioprinters offer this level of versatility. Pneumatic extrusion is on board of each GeSiM bioprinter, numerous tools can be configured with your order or added years later. The user interface fits into this philosophy and adapts to each individual combination of tools.

Most extrusion tools fit to all GeSiM instruments. The combination of 3D printed scaffolds with Nanolitre pipetting and microfluidics extends the field of TE to drug discovery, cell biology and more.

ÁRAJÁNLATOT, INFORMÁCIÓT KÉREK!

 

Smart Technology for Efficient Use

Internal design of a scaffold structure of two different material: Calciumphosphate and Alginate. 

Internal design of a scaffold structure of two different material: Calciumphosphate and Alginate.

  • Silent but smart XYZ-drives with Micrometer precision, individually Z-axes for print tools and optical components
  • Decentralized units for printing, media control and computing save your precious space in biosafety cabinets and ensure superb heat dissipation
  • Same software for all GeSiM bioprinters with easy to use CAD import
  • UV-light sources of different intensity/ costs on the print head; camera systems
  • Standard plastic cartridges as well as all Luer- lock nozzles can be used on all GeSiM bioprinters for 3d prints at room temperature
  • Automatic alignment of all nozzle sizes to the building platform
  • Print beds for SBS well plates with easy click fixation, temperature control and customized layouts available on request

GeSiM bioprinters are easy to operate in routine use:

Fully automatic adjustment of nozzles to the print bed (Left), the print bed size of BS5.1 (Right) fits to at least four SBS well plates or equivalent objects.

 

Nanolitre Pipetting

Tissue Engineering often raises interface and surface questions: How do cells adhere to artificial bones, implants and similar objects? What is the optimum scaffold geometry/ scaffold material to achieve appropriated cell adherence? Which cell line works, which doesn’t? Just throwing your ready-printed 3D object into a petri dish with cell suspension? – The Nanolitre pipetting module applies cells with spatial resolution during printing. Design and realization of complex artificial tissue with several cell types – partially applied to different parts of your 3D structure – becomes feasible.

The GeSiM Nanolitre Pipetting module allows up to 96 different cell suspensions or protein solutions for embedding into 3D structures during printing.

  • CAD – based tethering of cells/proteins to parts of a 3D structure during printing,
  • Volumes
  • Onboard washing allows subsequent liquid handling of different species with one tool,
  • Dispense volume ranges from 0.1 Nanolitre to Microlitres,
  • Twin adapter for micro pipets enables parallel aspiration of two species with subsequent droplet mixing at the target position.

Refer to the tab PRINT TOOLS for technical information on available dispensers.

The pipetting module transfers up to 96 samples on 3D structures during printing

The pipetting module transfers up to 96 samples on 3D structures during printing

 

Sterile Working

Tissue Engineering assembles living cells to biopolymers. 3D printing shall be done quickly, safe and in a sterile environment. Physiological conditions have to be maintained to protect your particular cell lines which often incorporate a lot of labour and resources.

GeSiM Bioprinters always come without lid/ HEPA filters. Our instruments are designed to be placed in a professional Biosafety Cabinet (BSC) or at least in a  laminar flow hood. The usual containments offer bench space for the manual preparation of bioinks immediately before 3D printing. It eliminates contamination risks when transferring your “living bioink” from another place to your 3D printer.

GeSiM collaborates with manufacturers of appropriated devices if you don’t have one in your lab.

BS5.1/E in a Kojair Biosafety Cabinet, setup in a “yellow room” (Courtesy of IBA Heiligenstadt) 

BS5.1/E in a Kojair Biosafety Cabinet (Class-II), setup in a “yellow room” (Courtesy of IBA Heiligenstadt)

The BS3.2 bioprinter in a TELSTAR biosafety cabinet

The BS3.2 bioprinter in a TELSTAR Aeolus laminar flow hood

 

Műszaki specifikációk

Instruments

BS3.3 Prime

The choice for beginners with potentially growing demands.

 

It is an attractively priced but complete bioprinter package:

  • One temperature-controlled print head,
  • LED UV-light, different wave lengths available,
  • Pneumatic and mechanical extrusion,
  • Syringe volumes from 10…50 Millilitres.

It prints a wide range of Hydrogels, Alginates and low-melting polymers like certain PCLs.

BS3.3

BS3.3 and it’s predecessors are in use for years in labs which paved the way for tissue engineering.

 

It is an individually configurable bioprinter for cutting-edge research. The range of available extrusion tools accepts almost any polymer of potential use in the field of TE.  It combines highest flexibility with compact dimensions and fits in many popular biosafety cabinets.

BS5.1

It’s the perfect companion for large research teams, core facilities and service providers with 24/7 operation.

Applikációk

 Applications at a Glance:

  • 3D Printing of very different (Bio-)polymers (can contain cells)
  • Design and print of porous – multi material – structures for tissue engineering
  • Co-printing of hard (E.g. PCL/PLA) and soft (E.g. Alginate) biopolymers (Sequential printing, co-axial extrusion, Nanolitre pipetting)
  • Functionalization of metal implants with soft polymer layers
  • Printing of micro structures from biopolymers by melt electro spinning/writing
  • Co-printing of two polymer melts through a gradient mixer

Highest Flexibility for a Changing World

GeSiM instruments incorporate highest modularity. Even when acquired for a particular project, additonal tools for upcoming projects are available at affordable costs.

Our budget line BS3.3 Prime comes with a fix combination of tools, whereas BS3.2 and BS5.1 can be configured almost arbitrarily. Here we show popular setups, please visit the preceding tab “Print Tools” for more information or download the brochure below.

Hardware upgrades mostly can be done without a service visit of GeSiM engineers (Limited for BS3.3 Prime). GeSiM permanently developes new tools/modules, probably fitting to your personal BioScaffold printer.  The user software GeSiM Robotics reconfigures easily and reflects always the actual status when adding new hardware. Tool-related pieces of software can be added similar to the download of apps for your phone.

The GeSiM factory service is available for older BioScaffold printers as well as for retrofitting of BS3.3 Primes with fix configuration.

2x 10mL cartridge with heaters; Camera; 30 mL cartridge, Piezo Pipet (From left)

2x 10mL cartridge with heaters; Camera; 30 mL cartridge, Piezo Pipet (From left)

Tartozékok, kiszerelések

Print Tools

 

GeSiM BioScaffold printers can be configured by numerous tools for different extrusion principles as well as optical components, like cameras and UV lamps.

The range of tools is continuously developing; please contact us for the latest catalogue. Bioinks and polymers with complex physical properties can be tested in advance for an optimum system configuration.

Always on board: Pneumatic Extruders

Mechanical Piston Extruders

Powerful motor driven piston extruders extend the capability of the pneumatic extrusion system. Very stiff polymers as well as materials showing increased viscoelasticity often require higher pressure for accurate prints.

The High-Temperature Extruder (HT-Extruder) with max. pressure > 100 bar is an unrivalled tool when th

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