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Axion BioSystems

Lumos

Lumos-24-v2
Lumos-96-v2 (1)
Lumos™ is a multiwell light delivery device allowing you to incorporate cutting-edge optical assay techniques, such as optogenetics, into your in vitro research.

With individual control of light delivery in each well, Lumos provides market-leading light intensities from up to four wavelengths. Providing ultimate assay flexibility, light delivery within each well is fully configurable with finely graded output intensity waveforms updated with microsecond scale precision. Light delivery is uniquely isolated within each well for fully independent assays across the microplate.

Lumos also pairs seamlessly with the Maestro Pro and Maestro Edge systems for simultaneous optical control and electrical measurement of cell network activity.

ÁRAJÁNLATOT, INFORMÁCIÓT KÉREK!

Key Features

 

Taking care of the assay so you can focus on the science.

  • High throughput - Simultaneous control of light delivery to each well of a standard SLAS-compliant 24-, 48-, or 96-well microplate.

  • Fully configurable - Powerful on-board electronics enable each of the 96 (Lumos 24) or 192 LEDs (Lumos 48 and Lumos 96) to be independently controlled with finely graded output intensities that are dynamically adjustable on a microsecond timescale.

  • Complete wavelength coverage - Four wavelengths per well span the visible spectrum for selective stimulation of the most-commonly used opsins.

  • Environmental control compatibility - Options for regulation of temperature and CO₂ enable extended benchtop experimentation.

  • User friendly software - Intuitive “drag-and-drop” style blocks enable quick and easy design of light delivery patterns and selection of target wells.

  • Topside light delivery - Delivery of light from above each well enables even light distribution and leaves the bottom of the microplate open for simultaneous electrophysiology, imaging, or other interfacing modalities.

  • Industry-leading light intensities - Large dynamic range with minimal cross-talk between wells.

  • Pairs with the Maestro MEA system - Seamless integration with the Maestro for optical control of cell activity during real-time recordings of functional responses.

Overview

Discover ground-breaking throughput, power, precision, and control in the first commercially available multiwell optical stimulation device. Incorporate cutting-edge optical techniques into your in vitro research using Axion BioSystems’ Lumos.

The Lumos system can be used in two general ways:

  • Control of cell biology – Deliver light to Axion’s Lumos OptiClear plates, standard-format SLAS-compatible microplates with optical specializations and clear bottom for cell biology applications such as gene editing and cell signaling.

  • Control of cell activity – Pair Lumos with Axion’s Maestro Pro and Edge platforms and deliver light to Axion’s Lumos MEA plates to precisely control networked excitable cells while simultaneously recording electrical responses.

Lumos standalone system

Use Lumos to control cell biology

Control cellular biology on a high-throughput scale

Light-mediated control of biochemical, genetic, and cellular functions is an emerging tool in many research fields:

  • Control intracellular signaling pathways
  • Direct gene expression with light
  • Edit genes with light-induced CRISPR/Cas9
  • Influence growth and regeneration

Lumos ECbase is compatible with standard lab warming plates and has a built-in gas delivery port to enable a controlled CO2 environment during Lumos Optical stimulation.

Lumos with MEA

Use Lumos to control cell activity

Control cell activity with light

Optogenetics techniques use genetic targeting to express light-sensitive ion channels called opsins (e.g. ChR2) in targeted cell populations. Upon stimulation by a specific wavelength of light, these opsins can be activated to shift the cell membrane potential. Light of specific wavelengths can thus be used to activate or silence cell activity in targeted cell populations.

Advantages of optogenetic-mediated control of cell activity include:

  • Artifact-free stimulation
  • Precise control of cell activity
  • Reduced experimental variability
  • Cell specific control

The most flexible in vitro optical stimulation system

A first-of-its-kind on the market, Lumos revolutionizes in vitro optical approaches. Lumos provides 24, 48, or 96 concurrent wells of stimulation and the ability to simultaneously use up to four different wavelengths of light per well at user-specified, precisely defined output patterns.

Lumos wavelengths
Lumos wavelength table guide

   

Axis Navigator - Stimulation Studio

The Neural Applications and Cardiac Applications modules support Lumos optical stimulation with Stimulation Studio in AxIS Navigator. Enabling fast, flexible set-up, Stimulation Studio provides intuitive, visual stimulation programming in an easily accessible plate map format. Here, each of the LEDs can be independently controlled for intensity (1-100% max power) and duration (down to 100 microseconds), and stimulation protocols can be designed quickly and easily with a drag-and-drop interface.

Stimulation Plate

 

Műszaki specifikációk

 

Lumos Optical Stimulation Systems

ModelCat No.# of Wells
# of Colors
LED colors
# of LEDs
Compatible Plates
Maestro
Edge
Maestro
Pro
Maestro
Z/ZHT
Maestro
Original
Lumos 24 LUMOS-SA-24 LUMOS-MEA-24
24
4
Lumos optogenetic system 24 well LED
96
Lumos MEA 24 Lumos Opticlear 24
   
Lumos 48 LUMOS-SA-48 LUMOS-MEA-48
48
4
Lumos optogenetic system 48 well LED
192
Lumos MEA 48 Lumos Opticlear 48
 
 
Lumos 96 LUMOS-SA-96 LUMOS-MEA-96
96
2
Lumos optogenetics systems 96-well LEDs
192
Lumos MEA 96 Lumos Opticlear 96
 
 
 

 

 

Applikációk

Related Applications

 

Cardiomyocyte Pacing

Control cardiomyocyte beat rate with optical or electrical stimulation to increase the physiological relevance of the assay
Inotropy
Characterize compound-induced effects on cardiomyocyte inotropy and excitation-contraction coupling
Neural Optical and Electrical Stimulation
Evoke neural activity with optical or electrical stimulation
Neuromuscular Junction
Record evoked skeletal myotube activity in functional iPSC-derived neuromuscular junctions
Retina
Record light-evoked electrical activity from primary retina slices and iPSC-derived retinal organoids
Zebrafish
Track neural activity, from zebrafish brain and spinal cord, label free

 

Tartozékok, kiszerelések

Lumos Optical Stimulation Systems

ModelCat No.# of Wells
# of Colors
LED colors
# of LEDs
Compatible Plates
Maestro
Edge
Maestro
Pro
Maestro
Z/ZHT
Maestro
Original
Lumos 24 LUMOS-SA-24 LUMOS-MEA-24
24
4
Lumos optogenetic system 24 well LED
96
Lumos MEA 24 Lumos Opticlear 24
   
Lumos 48 LUMOS-SA-48 LUMOS-MEA-48
48
4
Lumos optogenetic system 48 well LED
192
Lumos MEA 48 Lumos Opticlear 48
 
 
Lumos 96 LUMOS-SA-96 LUMOS-MEA-96
96
2
Lumos optogenetics systems 96-well LEDs
192
Lumos MEA 96 Lumos Opticlear 96
 
 
 
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