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PA 800 Plus Pharmaceutical Analysis System

HD_PA800 View02_WM_Final_12.17
HD_PA800 View02_Final_12.17
For research use only. Not for use in diagnostic procedures.

Therapeutic proteins make up a rapidly growing segment of global pharmaceutical production. These complex molecules require accurate characterization of product purity, heterogeneity, and identity. This includes data regarding their stability, shelf life and related manufacturing processes.

Automated and Quantitative Analysis of Biologics

The PA 800 Plus Pharmaceutical Analysis System* was designed in collaboration with biopharmaceutical development and QC groups. This platform provides analysts with robust and easy-to-use characterization, integrating quantitative, qualitative and automated solutions for protein purity, charge isoform distribution and glycan analysis. During the design of the PA 800 Plus, we emphasized assay portability, enhancing the overall system utility in multi-user, multi-instrument facilities.

For every researcher there is an ideal analytical technology—one that helps you achieve your goals.

ÁRAJÁNLATOT, INFORMÁCIÓT KÉREK!

Automated applications provide reproducible and quantitative results:

  • High resolution SDS-gel separation for protein purity determination
  • Automated, Quantitative IgG Purity Analysis
  • Advanced capillary Isoelectric Focusing (cIEF) for charge heterogeneity analysis
  • Carbohydrate profiling for assessment of glycoprotein microheterogeneity

Simplified operations and a robust platform enhance operational efficiency:

  • Specialized software quickly guides routine users from set-up through results
  • Innovations in system design ensure dependable operation and durability, with minimal maintenance
  • Modular UV, photodiode array and laser-induced fluorescence detectors can be easily interchanged

 

 

The PA 800 Plus Pharmaceutical Analysis System provides a comprehensive, automated, and quantitative solution for the characterization and analysis of proteins. Innovative system design ensures dependable operation and durability. The PA 800 Plus application menu includes SDS-gel molecular weight analysis, charge heterogeneity analysis utilizing advanced capillary isoelectric focusing technology, and carbohydrate profiling for the assessment of glycoprotein microheterogeneity. Modular design provides for the simple interchange of detectors.

The PA 800 Plus System includes:

  • High-resolution Separation Module
  • High-sensitivity UV, PDA, and Solid-state Laser-induced Fluorescence Detection
  • Sample Storage Temperature Control
  • High-speed System Controller with 32 Karat™ Version 9.0 and PA 800plus software
  • Validated Applications for SDS-MW, IgG, cIEF, and Glycan Analysis
  • Starter Kit Containing Necessary Hardware Supplies to Operate the System
  • Installation Qualification and Operation Qualification of the System
  • System Application Installation and Training

The PA 800 Plus Pharmaceutical Analysis system, the PA 800 Plus provides an automated and quantitative solution for the analysis of protein purity and molecular weight utilizing SDS-gel capillary electrophoresis. The innovative system design ensures dependable operation and durability. Additional detectors are available for future upgrades.

Műszaki specifikációk

A66528 PA 800 Plus Pharmaceutical Analysis System
Includes separation module with UV, photodiode array and LIF detection; system controller with PA 800 Plus software; system startup kit and reagents

A66527 PA 800S Plus Pharmaceutical Analysis System
Includes separation module with photodiode array detection; system controller with PA 800 Plus software; system startup kit and reagents

Dimensions:
Height: 29.2 in (74.2 cm)
Door Open: 38.8 in (98.6 cm)
Width: 25 in (63.5 cm)
Depth: 28.4 in (72.1 cm)

Weight (uncrated):
188 lbs (85.3 kg) (includes photodiode array detection)

Electrical Requirements:
Voltage: 100 - 240 V; 50/60 Hz

Voltage Range:
1 to 30 kV programmable at 0.1 kV increments

Current Range:
3 to 300 μA programmable at 0.1 μA increments

Pressure Delivery Range:
-5 to +100 psi

Sample Temperature Control:
4 - 60°C

Capillary Temperature Control:
15 - 60°C

Sample Trays: 2 x 96-well plates
2 x 48 universal vials 2 x 48 0.2 mL microvials

Buffer Tray:
2 x 36 universal vials

Detection Capability:
UV/Vis
200, 214, 254, 280 nm standard filter
190 - 600 nm (custom filter option)
Diode Array
190 - 600 nm (programmable)
0.5 - 32 Hz scan collection frequency (programmable)
Laser Induced Fluorescence (LIF)
300 - 700 nm excitation range
350 - 750 nm emission range
0 - 1000 RFU

Source Lasers with 3 mW Power Output:
488 nm solid-state laser (included in A66528)

Tartozékok, kiszerelések

A66528 PA 800 Plus Pharmaceutical Analysis System
Includes separation module with UV, photodiode array and LIF detection; system controller with PA 800 Plus software; system startup kit and reagents

A66527 PA 800S Plus Pharmaceutical Analysis System
Includes separation module with photodiode array detection; system controller with PA 800 Plus software; system startup kit and reagents

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